Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer

@inproceedings{Flaherty2017GlucocorticoidsIP,
  title={Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer},
  author={Renée Lee Flaherty and Matthew Owen and Aidan Fagan-Murphy and Haya Intabli and D. Healy and Anika Patel and Marcus C. Allen and Bhavik Anil Patel and Melanie S. Flint},
  booktitle={Breast Cancer Research},
  year={2017}
}
BackgroundPsychological stress increases the circulating levels of the stress hormones cortisol and norepinephrine (NE). Chronic exposure to elevated stress hormones has been linked to a reduced response to chemotherapy through induction of DNA damage. We hypothesize that stress hormone signalling may induce DNA damage through the production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and interference in DNA repair processes, promoting tumourigenesis.MethodsBreast cancer… CONTINUE READING
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J Bain, L Plater, +4 authors inhibitors et al. The selectivity of protein kinase
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