Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle.

@article{Fishel1995GlucocorticoidsIA,
  title={Glucocorticoids induce angiotensin-converting enzyme expression in vascular smooth muscle.},
  author={Rhonda S Fishel and Susan J. Eisenberg and Shrot Shai and Robert A. Redden and K. E. Bernstein and Bradford C. Berk},
  journal={Hypertension},
  year={1995},
  volume={25 3},
  pages={343-9}
}
Angiotensin-converting enzyme (ACE) activity plays a central role in vessel growth and remodeling as shown by the fact that ACE inhibitors reduce neointimal proliferation after rat carotid injury. To investigate the mechanisms that regulate smooth muscle cell ACE expression, we studied the effects of steroids on ACE activity and mRNA in cultured rat aortic smooth muscle cells. ACE activity was present at low levels independent of growth state. In response to the glucocorticoid dexamethasone… CONTINUE READING