Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats.

@article{Shimizu2008GlucocorticoidsIN,
  title={Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats.},
  author={Hiroshi Shimizu and Hiroshi Arima and Minemori Watanabe and Motomitsu Goto and Ryoichi Banno and Ikuko Sato and Nobuaki Ozaki and Hiroshi Nagasaki and Yutaka Oiso},
  journal={Endocrinology},
  year={2008},
  volume={149 9},
  pages={4544-53}
}
Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in the hypothalamus is the master regulator of energy balance. We reported in previous studies that glucocorticoids play a permissive role in the regulation of orexigenic neuropeptide Y (Npy) gene expression in the arcuate nucleus. In this study, we examined whether any cross talk occurs between glucocorticoids and AMPK signaling in the hypothalamus to regulate Npy as well as agouti-related peptide (Agrp) gene… CONTINUE READING
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