Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures.

@article{Shimizu2010GlucocorticoidsIN,
  title={Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures.},
  author={Hiroshi Shimizu and Hiroshi Arima and Yoshiharu Ozawa and Minemori Watanabe and Ryoichi Banno and Yoshihisa Sugimura and Nobuaki Ozaki and Hiroshi Nagasaki and Yutaka Oiso},
  journal={Peptides},
  year={2010},
  volume={31 1},
  pages={145-9}
}
The mammalian target of rapamycin (mTOR) has been implicated in the regulation of physiological functions such as cell growth and proliferation, and glucocorticoids reportedly inhibit mTOR signaling in peripheral tissues. Recent studies suggest that the mTOR signaling in the hypothalamus plays a critical role in maintaining energy homeostasis. In this study, we examined whether the mTOR signaling in the hypothalamus is involved in the regulation of neuropeptide Y (Npy) gene expression in the… CONTINUE READING

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