Glucocorticoids increase CD4CD25 cell percentage and Foxp3 expression in patients with multiple sclerosis.

@article{Braitch2009GlucocorticoidsIC,
  title={Glucocorticoids increase CD4CD25 cell percentage and Foxp3 expression in patients with multiple sclerosis.},
  author={Manjit Braitch and Sreedharan Harikrishnan and Richard A Robins and Calen Nichols and Angela J. Fahey and Louise C. Showe and Cris S. Constantinescu},
  journal={Acta neurologica Scandinavica},
  year={2009},
  volume={119 4},
  pages={239-45}
}
OBJECTIVES To determine whether percentages of CD4(+)CD25(high) T cells (a group of regulatory T cells, Treg) differ in patients with multiple sclerosis (MS) in relapse vs remission after glucocorticoid treatment and whether treatment for relapses changes Treg population and the expression of Foxp3, a key Treg-associated molecule. MATERIALS AND METHODS Peripheral blood mononuclear cells (PBMC) were obtained from 20 patients with MS during relapse, just before and 2 days after starting steroid… CONTINUE READING

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