Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action.

@article{Kerachian2009GlucocorticoidsIO,
  title={Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action.},
  author={Mohammad Amin Kerachian and Chantal S{\'e}guin and Edward Joseph Harvey},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2009},
  volume={114 3-5},
  pages={121-8}
}
Glucocorticoid (GC) usage is the most common non-traumatic cause of osteonecrosis of the femoral head (ON). Despite the strong association of GC with ON, the underlying mechanisms have been unclear. Investigators have proposed both direct and indirect effects of GC on cells. Indirect and direct mechanisms remain intimately related and often result in positive feedback loops to potentiate the disease processes. However, the direct effects, in particular apoptosis, have recently been shown to be… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

Primary epiphyseal arteriopathy in a mouse model of steroid-induced osteonecrosis.

The American journal of pathology • 2013
View 15 Excerpts
Highly Influenced

Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats.

International journal of biological sciences • 2016
View 5 Excerpts
Highly Influenced

Effects of P-Glycoprotein on Steroid-Induced Osteonecrosis of the Femoral Head

Calcified Tissue International • 2010
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…