Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure.

@article{Liu2011GlucocorticoidsIR,
  title={Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure.},
  author={Chao Liu and Ying Chen and Yunxiao Kang and Zhihua Ni and Heming Xiu and Jing Guan and Kunshen Liu},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={339 1},
  pages={
          203-9
        }
}
  • Chao Liu, Ying Chen, +4 authors Kunshen Liu
  • Published in
    The Journal of pharmacology…
    2011
  • Medicine
  • In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased expression of natriuretic peptide receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent diuresis and natriuresis in patients with heart failure, but the precise mechanism is unclear. In the… CONTINUE READING

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