Glucocorticoids have pleiotropic effects on small intestinal crypt cells.

@article{Quaroni1999GlucocorticoidsHP,
  title={Glucocorticoids have pleiotropic effects on small intestinal crypt cells.},
  author={Andrea Quaroni and Jean Q Tian and Michael G{\"o}ke and Daniel K. Podolsky},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={277 5},
  pages={G1027-G1040}
}
Glucocorticoids have long been known to accelerate maturation of the intestinal tract, but the molecular mechanisms that account for their physiological function in the epithelium remain poorly characterized. Using rat intestinal epithelial cell lines (IEC-6, IEC-17, and IEC-18) as models, we have characterized glucocorticoid receptors in crypt cells and documented striking morphological, ultrastructural, and functional alterations induced by these hormones in intestinal cells. They include… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 77 references

Quaroni . Involvement of p 21 ( WAF 1 / Cip 1 ) and p 27 ( Kip 1 ) in intestinal epithelial cell differentiation

J. Q. Tian, A.
Am . J . Physiol . 276 ( Cell Physiol . • 1999

Role of the CCAAT/enhancer binding protein-a transcription factor in the glucocorticoid stimulation of p2lwaf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells

E. J. Cram, R. A. Ramost, +3 authors G. L. Firestone
J. Biol • 1998
View 1 Excerpt

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