Glucocorticoids have pleiotropic effects on small intestinal crypt cells.

  title={Glucocorticoids have pleiotropic effects on small intestinal crypt cells.},
  author={Andrea Quaroni and Jean Q Tian and Michael G{\"o}ke and Daniel K. Podolsky},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={277 5},
Glucocorticoids have long been known to accelerate maturation of the intestinal tract, but the molecular mechanisms that account for their physiological function in the epithelium remain poorly characterized. Using rat intestinal epithelial cell lines (IEC-6, IEC-17, and IEC-18) as models, we have characterized glucocorticoid receptors in crypt cells and documented striking morphological, ultrastructural, and functional alterations induced by these hormones in intestinal cells. They include… CONTINUE READING


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