Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets.

@article{Huising2011GlucocorticoidsDR,
  title={Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets.},
  author={Mark O. Huising and Anna P. Pilbrow and Misako Matsumoto and Talitha van der Meulen and Hoyong Park and Joan M. Vaughan and Sojin Lee and Wylie W. Vale},
  journal={Endocrinology},
  year={2011},
  volume={152 1},
  pages={
          138-50
        }
}
Urocortin 3 (Ucn 3), member of the corticotropin-releasing factor (CRF) family of peptide hormones, is released from β-cells to potentiate insulin secretion. Ucn 3 activates the CRF type-2 receptor (CRFR2) but does not activate the type-1 receptor (CRFR1), which was recently demonstrated on β-cells. While the direct actions of Ucn 3 on insulin secretion suggest the presence of cognate receptors within the islet microenvironment, this has not been established. Here we demonstrate that CRFR2α is… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 2011
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