Glucocorticoids differentially increase nerve growth factor and basic fibroblast growth factor expression in the rat brain

@inproceedings{Mocchetti1996GlucocorticoidsDI,
  title={Glucocorticoids differentially increase nerve growth factor and basic fibroblast growth factor expression in the rat brain},
  author={I. Mocchetti and G. Spiga and V. Hayes and P. Isackson and A. Colangelo},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996}
}
  • I. Mocchetti, G. Spiga, +2 authors A. Colangelo
  • Published in
    The Journal of neuroscience…
    1996
  • Chemistry, Medicine
  • Adrenocorticotropin hormone (ACTH) and adrenal steroids may influence trophic processes operative in neuronal plasticity. Because nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) participate in neuronal trophism, we have investigated whether adrenal steroids induce the expression of these two trophic factors in the rat brain. The systemic administration of dexamethasone (DEX) elicited a rapid (within 3 hr) and sustained accumulation of bFGF and NGF mRNA in the cerebral cortex… CONTINUE READING
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