Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.

@article{Shi2010GlucocorticoidsDS,
  title={Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.},
  author={Jian-hua Shi and Wen-hua Du and Xiaoyan Liu and Yan-ping Fan and X Hu and Hai-yan Zhou and H Xu and Xiao-mei Zhang and Ping Xiang and Feng-ling Chen},
  journal={Steroids},
  year={2010},
  volume={75 12},
  pages={853-8}
}
OBJECTIVE Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expression in vitro, there exist discrepant results in vivo. In this study, we observe the effect of GC on the serum adiponectin level and adiponectin expression in white adipose tissue (WAT) in male SD rats. METHODS An obese rat model was made by a high-fat diet. Both non-obese and obese… CONTINUE READING
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