Glucocorticoids control beta-catenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells.

@article{Guan2004GlucocorticoidsCB,
  title={Glucocorticoids control beta-catenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells.},
  author={Yi Guan and Nicola M Rubenstein and Kim L Failor and Paul L Woo and Gary L. Firestone},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 1},
  pages={214-27}
}
In Con8 rat mammary epithelial tumor cells, the synthetic glucocorticoid dexamethasone stimulates the remodeling of tight junctions and adherens junctions before formation of highly sealed tight junctions. In this study, the expression and localization of key components of the apical junction were examined as potential targets of glucocorticoid signaling… CONTINUE READING