Glucocorticoids can induce PTSD-like memory impairments in mice.

  title={Glucocorticoids can induce PTSD-like memory impairments in mice.},
  author={Nadia Kaouane and Yves Porte and Monique Vall{\'e}e and Laurent Brayda-Bruno and Nicole E Mons and Ludovic Calandreau and Aline Marighetto and Pier Vincenzo Vincenzo Piazza and Aline Desmedt},
  volume={335 6075},
Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue… CONTINUE READING
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