Glucocorticoids are modulators of GABAA receptors in brain.

  title={Glucocorticoids are modulators of GABAA receptors in brain.},
  author={Maria Dorota Majewska and Jean Claude Bisserbe and Robert L. Eskay},
  journal={Brain research},
  volume={339 1},
Modulation of binding of [3H]muscimol, a GABAA receptor agonist, by natural and synthetic glucocorticoids was investigated in crude synaptosomal membranes and in brain sections of rat. In adrenalectomized (Adx) rats, muscimol binding was reduced by 30-50% in cerebral cortex, cerebellum, thalamus and hippocampus, as compared to sham-operated controls. This decrease was due to reduced binding affinities of GABA receptors for muscimol. In contrast muscimol binding was increased by 38% in the… CONTINUE READING