Glucocorticoids and the Th1/Th2 balance.

  title={Glucocorticoids and the Th1/Th2 balance.},
  author={Ilia J. Elenkov},
  journal={Annals of the New York Academy of Sciences},
  • Ilia J. Elenkov
  • Published 2004 in Annals of the New York Academy of Sciences
Evidence accumulated over the last 5-10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and tumor necrosis factor (TNF)-alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL-4, IL-10, and IL-13 by Th2 cells. Through this mechanism increased levels of GCs may systemically cause a selective suppression of the Th1-cellular immunity axis, and a shift toward Th2-mediated… CONTINUE READING