Glucocorticoids and the Th1/Th2 Balance

@article{Elenkov2004GlucocorticoidsAT,
  title={Glucocorticoids and the Th1/Th2 Balance},
  author={Ilia J. Elenkov},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1024}
}
  • I. Elenkov
  • Published 2004
  • Medicine
  • Annals of the New York Academy of Sciences
Abstract: Evidence accumulated over the last 5‐10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)‐12, interferon (IFN)‐γ, IFN‐α, and tumor necrosis factor (TNF)‐α by antigen‐presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL‐4, IL‐10, and IL‐13 by Th2 cells. Through this mechanism increased levels of GCs may systemically cause a selective suppression of the Th1‐cellular immunity axis, and a shift toward Th2‐mediated… Expand
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