Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy.

@article{Hardy2018GlucocorticoidsAB,
  title={Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy.},
  author={R. H. Stephen Hardy and Hong Zhou and Markus J. Seibel and Mark Stuart Cooper},
  journal={Endocrine reviews},
  year={2018},
  volume={39 5},
  pages={
          519-548
        }
}
Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. Additionally, in recent years it has become clear that more subtle states of endogenous glucocorticoid excess may have a major impact on bone health. Adverse effects can be seen with mild systemic glucocorticoid excess, but there is also evidence of tissue-specific regulation of glucocorticoid action within bone as a mechanism of disease. This review article examines (1) the role of… CONTINUE READING
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