Glucocorticoids and 11β-hydroxysteroid dehydrogenases: mechanisms for hypertension.

@article{Hunter2015GlucocorticoidsA1,
  title={Glucocorticoids and 11β-hydroxysteroid dehydrogenases: mechanisms for hypertension.},
  author={Robert William Hunter and Matthew A Bailey},
  journal={Current opinion in pharmacology},
  year={2015},
  volume={21},
  pages={
          105-14
        }
}
Glucocorticoid excess induces hypertension, in which abnormal renal sodium homeostasis is implicated. It is common in industrialised nations where hypertension remains the major risk-factor for cardiovascular disease. Aldosterone is the dominant chronic regulator in sodium homeostasis, but glucocorticoids influence renal sodium transport through mineralocorticoid and glucocorticoid receptor activation, particularly in disease. Here we focus on the 11β-hydroxysteroid dehydrogenase enzymes, which… CONTINUE READING
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