Glucocorticoids Preserve Calpastatin and Troponin I during Cardiopulmonary Bypass in Immature Pigs

@article{Schwartz2003GlucocorticoidsPC,
  title={Glucocorticoids Preserve Calpastatin and Troponin I during Cardiopulmonary Bypass in Immature Pigs},
  author={Steven M. Schwartz and Jodie Y. Duffy and Jeffrey M. Pearl and Semin Goins and Connie J. Wagner and David P. Nelson},
  journal={Pediatric Research},
  year={2003},
  volume={54},
  pages={91-97}
}
Degradation of troponin I (TnI) by calpain occurs with myocardial stunning in ischemia-reperfusion injury. Glucocorticoids attenuate myocardial ischemia-reperfusion injury, but their effect on TnI degradation is unknown. A piglet model was used to test the hypotheses that cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are associated with TnI degradation and that TnI alterations could be prevented by glucocorticoid treatment. Piglets were cooled to 18°C, subjected to… CONTINUE READING

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