Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure
@article{Liu2011GlucocorticoidsIR, title={Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure}, author={Chao Liu and Y. Chen and Yunxiao Kang and Zhi-yong Ni and Heming Xiu and Jing Guan and K. Liu}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2011}, volume={339}, pages={203 - 209} }
In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased expression of natriuretic peptide receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent diuresis and natriuresis in patients with heart failure, but the precise mechanism is unclear. In the… Expand
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References
SHOWING 1-10 OF 44 REFERENCES
Modulation of exogenous and endogenous atrial natriuretic peptide by a receptor inhibitor.
- Chemistry, Medicine
- Hypertension
- 1994
- 32
- PDF
Inhibition of Dehydration-Induced Water Intake by Glucocorticoids Is Associated with Activation of Hypothalamic Natriuretic Peptide Receptor-A in Rat
- Medicine
- PloS one
- 2010
- 28
- PDF
Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations.
- Medicine
- American journal of physiology. Renal physiology
- 2007
- 47
- PDF
Gene for the rat atrial natriuretic peptide is regulated by glucocorticoids in vitro.
- Biology, Medicine
- The Journal of clinical investigation
- 1988
- 75
- PDF
Atrial Natriuretic Factor Effects on Cyclic Nucleotides in a Human Renal Cell Line
- Biology, Medicine
- Hypertension
- 1989
- 7
- PDF
Permissive action of glucocorticoid substitution therapy on the effects of atrial natriuretic peptide (hANP) in patients with adrenocortical insufficiency.
- Medicine
- Experimental and clinical endocrinology
- 1990
- 9
Blunted cGMP response to agonists and enhanced glomerular cyclic 3',5'-nucleotide phosphodiesterase activities in experimental congestive heart failure.
- Chemistry, Medicine
- Kidney international
- 1996
- 82
Local modulation of the natriuretic peptide system in the rat remnant kidney.
- Medicine
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- 2009
- 10
- PDF
Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.
- Medicine
- The Journal of clinical investigation
- 1986
- 714
- PDF
Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.
- Medicine, Biology
- The Journal of clinical investigation
- 1985
- 209
- PDF