Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure

@article{Liu2011GlucocorticoidsIR,
  title={Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure},
  author={Chao Liu and Y. Chen and Yunxiao Kang and Zhi-yong Ni and Heming Xiu and Jing Guan and K. Liu},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2011},
  volume={339},
  pages={203 - 209}
}
  • Chao Liu, Y. Chen, +4 authors K. Liu
  • Published 2011
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased expression of natriuretic peptide receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent diuresis and natriuresis in patients with heart failure, but the precise mechanism is unclear. In the… Expand
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