Glucocorticoids: protectors of the brain during innate immune responses.

  title={Glucocorticoids: protectors of the brain during innate immune responses.},
  author={Isaias Glezer and Serge Rivest},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={10 6},
The innate immune response is a coordinated set of reactions involving cells of myeloid lineage and a network of signaling molecules. Such a response takes place in the CNS during trauma, stroke, spinal cord injury, and neurodegenerative diseases, suggesting that macrophages/microglia are the cells that perpetuate the progressive neuronal damage. However, there is accumulating evidence that these cells and their secreted proinflammatory molecules have more beneficial effects than detrimental… CONTINUE READING