Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma.

  title={Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma.},
  author={Vincent H J van der Velden},
  journal={Mediators of Inflammation},
  pages={229 - 237}
GLUCOCORTICOIDS are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in particular activating protein-1 or nuclear factor-kappaB. Glucocorticoids inhibit many inflammation-associated molecules… CONTINUE READING

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