Glucocorticoids, cytokines and brain abnormalities in depression.

  title={Glucocorticoids, cytokines and brain abnormalities in depression.},
  author={Patricia Ana Zunszain and Christoph Anacker and Annamaria Cattaneo and L{\'i}via A. Carvalho and Carmine M Pariante},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={35 3},
Major depression (MD) is a common psychiatric disorder with a complex and multifactor aetiology. Potential mechanisms associated with the pathogenesis of this disorder include monoamine deficits, hypothalamic-pituitary-adrenal (HPA) axis dysfunctions, inflammatory and/or neurodegenerative alterations. An increased secretion and reactivity of cortisol together with an altered feedback inhibition are the most widely observed HPA abnormalities in MD patients. Glucocorticoids, such as cortisol, are… CONTINUE READING


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