Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity.

@article{Vallelian2010GlucocorticoidTS,
  title={Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity.},
  author={Florence Vallelian and C A Schaer and Theresa Kaempfer and Peter Max Gehrig and Elena Duerst and Gabriele Schoedon and Dominik J Schaer},
  journal={Blood},
  year={2010},
  volume={116 24},
  pages={5347-56}
}
Glucocorticoids are used extensively to treat autoimmune hemolytic anemias. Some beneficial effects of glucocorticoid pulse therapy have also been reported in sickle cell disease and paroxysmal nocturnal hemoglobinuria. Based on established concepts of hemoglobin (Hb) toxicity and physiologic Hb scavenger systems, we evaluated whether glucocorticoids could support an adaptive response to extracellular Hb independently of their immunosuppressive activities. Using global proteome and… CONTINUE READING

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