Glucocorticoid treatment of girls with congenital adrenal hyperplasia: effects on height, sexual maturation, and fertility.

@article{Klingensmith1977GlucocorticoidTO,
  title={Glucocorticoid treatment of girls with congenital adrenal hyperplasia: effects on height, sexual maturation, and fertility.},
  author={Georgeanna Jones Klingensmith and S. Garc{\'i}a and Howard Wilber Jones and Claude J. Migeon and Robert M Blizzard},
  journal={The Journal of pediatrics},
  year={1977},
  volume={90 6},
  pages={
          996-1004
        }
}
Ninety-eight females with congenital adrenal hyperplasia due to a defect in either the 21-hydroxylase or the 11 beta-hydroxylase enzyme were evaluated to determine the effects of glucocorticoid treatment on growth, pubertal development, and fertility. When treatment was begun prior to one year of age, mean final height was 157.4 +/- 7.3 com, well within the normal adult female range, and significantly (p less than 0.001) greater than the mean final height of 150.9 +/- 4.3 cm found in untreated… CONTINUE READING