Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man.

@article{Barber1993GlucocorticoidTA,
  title={Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man.},
  author={Annabel E. Barber and Susette M. Coyle and Michael A. Marano and Eva M. Fischer and Steve E. Calvano and Yuman Fong and Lyle L. Moldawer and Stephen F. Lowry},
  journal={Journal of immunology},
  year={1993},
  volume={150 5},
  pages={1999-2006}
}
Previous experimental data have demonstrated that steroid pretreatment regulates endotoxin-elicited cytokine production. The timing of such hypercortisolemia also appears to be a major determinant of both the systemic and the cytokine response to infectious stimuli. Our study was undertaken to further study the in vivo influence of glucocorticoid infusion concurrent with and before endotoxin exposure in man. A total of 23 normal human subjects were given endotoxin (LPS) alone or pretreated with… CONTINUE READING

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