Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder.

@article{Rohleder2010GlucocorticoidSO,
  title={Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder.},
  author={Nicolas Rohleder and Jutta Manuela Wolf and Oliver T. Wolf},
  journal={Neuroscience and biobehavioral reviews},
  year={2010},
  volume={35 1},
  pages={104-14}
}
Both hyper- and hypo-activity of the hypothalamus-pituitary-adrenal (HPA) axis activity are a consistently reported hallmark feature of stress-related disorders, such as major depression and posttraumatic stress disorder (PTSD), respectively. In this manuscript, however, we are summarizing evidence pointing to altered glucocorticoid (GC) sensitivity in relevant target tissues for HPA axis hormones. Specifically, we provide a summary of GC effects on cognitive functions, as an emerging marker… CONTINUE READING