Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression.

@article{Liu2009GlucocorticoidRE,
  title={Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression.},
  author={Yong Liu and Domagoj Mladinov and Jennifer L. Pietrusz and Kristie S Usa and Mingyu Liang},
  journal={Cardiovascular research},
  year={2009},
  volume={81 1},
  pages={
          140-7
        }
}
AIMS Hypertensive and other effects of excess glucocorticoids might be in part mediated by the suppression of endothelial nitric oxide synthase (eNOS) expression. We studied the transcriptional and biochemical mechanisms that mediate or modulate the suppression of eNOS expression by glucocorticoids. METHODS AND RESULTS We found that a mere three-fold increase in the concentration of the natural glucocorticoid cortisol (from 30 to 100 nmol/L) significantly decreased the expression level of… CONTINUE READING
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