Glucocorticoid resistance and the immune function in the immunodeficiency syndrome.

@article{Norbiato1998GlucocorticoidRA,
  title={Glucocorticoid resistance and the immune function in the immunodeficiency syndrome.},
  author={Guido Norbiato and Maurizio Bevilacqua and Tarc{\'i}sio Mauro Vago and Marco Clerici},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={840},
  pages={
          835-47
        }
}
Glucocorticoids, the final product of HPA axis, and their receptors (GRs) on mononuclear cells are crucial mediators in the endocrine-immune interaction. An alteration in GRs involving a lower receptor affinity (Kd) for glucocorticoids has been found in a group of advanced AIDS patients, who developed Addisonian symptoms (weakness, weight loss, hypotension, hyponatremia, and intense mucocutaneous melanosis) in spite of hypercortisolism and normal or slightly elevated values of ACTH (AIDS-GR… CONTINUE READING

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