Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels.

Abstract

Activation of the stress axis by glucocorticoids suppresses reproductive function in many species. Here, we performed studies to determine whether these effects are mediated at the level of the hypothalamus or pituitary or both, and to dissect the underlying molecular mechanisms, using two established rodent models. Rats were treated either chronically or… (More)

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