Glucocorticoid regulation of the serotonergic system of the brain.

  • Paul Y. Sze
  • Published 1976 in Advances in biochemical psychopharmacology
Glucorticoids at concentrations above 10(-7) M stimulate the uptake of tryptophan by brain synaptosomes. Furthermore, in both developmental and drug-induced (reserpine and ethanol) increases of brain tryptophan hydroxylase activity, glucocorticoids are required in order for the increases to occur. If de novo enzyme synthesis is assumed to take place in such… CONTINUE READING