Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback.

@article{Watts2005GlucocorticoidRO,
  title={Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback.},
  author={Alan G. Watts},
  journal={Frontiers in neuroendocrinology},
  year={2005},
  volume={26 3-4},
  pages={109-30}
}
This review will examine our current knowledge of a fundamental property of CRH neuroendocrine neurons: how the major endpoint of the HPA axis--adrenal glucocorticoids--interacts with the mechanisms controlling the expression of the genes that encode ACTH secretogogues. A great deal of work over the past 25 years has led to the notion that this question has an ostensibly simple answer: glucocorticoids inhibit peptide gene expression using "negative feedback" at the CRH neuron and elsewhere… CONTINUE READING

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