Glucocorticoid regulation of metallothionein during murine development.

  title={Glucocorticoid regulation of metallothionein during murine development.},
  author={Carol J. Quaife and Robert Hammer and Nicholas Mottet and Richard D Palmiter},
  journal={Developmental biology},
  volume={118 2},
During the second half of gestation in the mouse there is a rise in both fetal (4-fold) and maternal (10-fold) metallothionein-I (MT-I) mRNA in the liver (but not in the kidney). There is a large increase in plasma corticosterone (the predominant murine glucocorticoid hormone), as well as an increase in hepatic zinc, which is coincident with the induction of MT-I mRNA. Considering that both of these compounds are known to be effective inducers of MT-I mRNA, we set out to determine whether… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Cellular Signals Controlling Uterine Function

Lynn A. Lavla
Springer US • 1991
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…