Glucocorticoid regulation of hypothalamic proopiomelanocortin.

  title={Glucocorticoid regulation of hypothalamic proopiomelanocortin.},
  author={Sharon L Wardlaw and Kathryn McCarthy and Irene Conwell},
  volume={67 1},
Although glucocorticoids clearly inhibit proopiomelanocortin (POMC) gene transcription and peptide synthesis in the anterior pituitary, the effects of glucocorticoids on POMC in the hypothalamus are still unclear, even though most POMC neurons in the arcuate nucleus are known to have glucocorticoid receptors. In this study, we have therefore examined the effect of adrenalectomy (ADX) and glucocorticoid replacement on POMC mRNA and peptide (beta-EP and alpha-MSH) levels in the medial basal… CONTINUE READING