Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.

@article{Koyanagi2006GlucocorticoidRO,
  title={Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.},
  author={Satoru Koyanagi and Hinako Suyama and Yukako Kuramoto and Noaya Matsunaga and Hiroshi Takane and Shinji Soeda and Hiroshi Shimeno and Shun Higuchi and Shigehiro Ohdo},
  journal={Endocrinology},
  year={2006},
  volume={147 11},
  pages={5034-40}
}
Although the antiviral effect of interferon (IFN) varies depending on 24-h oscillation in the expression of its specific receptor, the mechanism of oscillation remains to be clarified. Here we report that oscillation in the expression of the IFN receptor gene (IFN-alpha/beta R1) in mouse liver is caused by the endogenous rhythm of glucocorticoid secretion. Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-alpha… CONTINUE READING