Glucocorticoid-regulated transcription factors.

  title={Glucocorticoid-regulated transcription factors.},
  author={Ian M. Adcock},
  journal={Pulmonary pharmacology & therapeutics},
  volume={14 3},
  • Ian M. Adcock
  • Published 2001 in Pulmonary pharmacology & therapeutics
Glucocorticoids are the most effective antiinflammatory drugs used in the treatment of asthma. They act by binding to a specific receptor (GR) that, upon activation, translocates to the nucleus and either increases (transactivates) or decreases (transrepresses) gene expression. Inhibition of pro-inflammatory transcription factors such as activator protein (AP)-1, signal transducers and activators of transcription (STATs), nuclear factor of activated T cells (NFAT) and nuclear factor (NF)-kappa… CONTINUE READING
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