Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia

  title={Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia},
  author={Johannes Rainer and Christian Ploner and Simone Jesacher and Andreas Ploner and Mayra Eduardoff and Muhammad Zeeshan Mansha and Muhammad Wasim and Renate E Panzer-Gr{\"u}mayer and Zlatko Trajanoski and Harald Niederegger and Reinhard Kofler},
Glucocorticoids (GCs) induce apoptosis in lymphoid lineage cells and are therefore used in the therapy of acute lymphoblastic leukemia (ALL) and related malignancies. MicroRNAs (miRNAs) and the related mirtrons are ∼22 nucleotide RNAs derived from polymerase-II transcripts and implicated in the control of essential biological functions, including apoptosis. Whether GCs regulate miRNA-encoding transcription units is unknown. We investigated miRNA/mirtron expression and GC regulation in 8… CONTINUE READING


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