Glucocorticoid receptors participate in the opiate withdrawal‐induced stimulation of rats NTS noradrenergic activity and in the somatic signs of morphine withdrawal

@article{NavarroZaragoza2012GlucocorticoidRP,
  title={Glucocorticoid receptors participate in the opiate withdrawal‐induced stimulation of rats NTS noradrenergic activity and in the somatic signs of morphine withdrawal},
  author={J. Navarro-Zaragoza and J. Hidalgo and M. L. Laorden and M. Milan{\'e}s},
  journal={British Journal of Pharmacology},
  year={2012},
  volume={166}
}
  • J. Navarro-Zaragoza, J. Hidalgo, +1 author M. Milanés
  • Published 2012
  • Medicine
  • British Journal of Pharmacology
  • BACKGROUND AND PURPOSE Recent evidence suggests that glucocorticoid receptor (GR) is a major molecular substrate of addictive properties of drugs of abuse. Hence, we performed a series of experiments to further characterize the role of GR signalling in opiate withdrawal‐induced physical signs of dependence, enhanced noradrenaline (NA) turnover in the hypothalamic paraventricular nucleus (PVN) and tyrosine hydroxylase (TH) phosphorylation (activation) as well as GR expression in the nucleus of… CONTINUE READING
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