Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
@article{Pariante2001GlucocorticoidRI, title={Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment}, author={Carmine Maria Pariante and Andrew H. Miller}, journal={Biological Psychiatry}, year={2001}, volume={49}, pages={391-404} }
1,090 Citations
Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders
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Evidence is presented suggesting that membrane steroid transporters such as the multidrug resistance p-glycoprotein, which regulate access of glucocorticoids to the brain, could be a fundamental target of antidepressant treatment.
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Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment
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The glucocorticoid receptor: part of the solution or part of the problem?
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It is concluded that a lack of the ‘positive’ effects of cortisol on the brain, because of glucocorticoid resistance, is likely to be involved in the pathogenesis of depression.
Glucocorticoid Receptor Function In Vitro in Patients with Major Depression
- Biology, PsychologyStress
- 2004
In vitro studies are of particular relevance to understand the molecular mechanisms underlying GR abnormalities in patients with major depression and its regulation by antidepressant treatment, according to this review.
Glucocorticoid receptor dysfunction: consequences for the pathophysiology and treatment of mood disorders
- Medicine, PsychologyIndian journal of psychiatry
- 2003
HPA axis dysfunction is prevalent in patients with mood disorder, particularly those with psychotic disorders and bipolar affective disorder, and preliminary findings suggest that it is a potential target for novel therapies.
Risk Factors for Development of Depression and Psychosis
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 2009
Clinical and experimental studies do not support the notion that “high levels of glucocorticoids” always have a depressogenic effect, nor that decreasing the effects of these hormones always has an antidepressant effects.
The glucocorticoid hypothesis of depression: History and prospects
- Biology, PsychologyRussian Journal of Genetics: Applied Research
- 2017
The purpose of this review was to analyze the available published data on the effects of stress and glucocorticoids on the expression of GRs in the hippocampus, which is traditionally considered as the most sensitive to stress brain structure, and the implication of the interplay ofGRs and BDNF in the pathogenesis of stress-related disorders.
In vitro modulation of the glucocorticoid receptor by antidepressants
- Biology, PsychologyStress
- 2008
The in vitro studies that have examined the effect of antidepressants on GR expression, number and function in human and animal cell lines are reviewed, and the possible molecular mechanisms underlying these effects are reviewed.
Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression
- Psychology, BiologyBiological Psychiatry
- 2006
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