Glucocorticoid receptor variant and risk of dementia and white matter lesions.

  title={Glucocorticoid receptor variant and risk of dementia and white matter lesions.},
  author={Elisabeth F. C. van Rossum and Frank Jan de Jong and Jan Willem Koper and Andr{\'e} G. Uitterlinden and Niels Dani{\"e}l Prins and Ewoud J van Dijk and Peter J Koudstaal and Albert Hofman and Frank H. de Jong and Steven W. J. Lamberts and Monique M. B. Breteler},
  journal={Neurobiology of aging},
  volume={29 5},
OBJECTIVE Elevated glucocorticoid levels are associated with dementia. A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities. METHODS This study was performed in two prospective population-based cohort studies among elderly. The first study included 6034 participants who were screened for dementia (mean follow-up 5.8 years). The second… CONTINUE READING

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