Glucocorticoid receptor variant and risk of dementia and white matter lesions

  title={Glucocorticoid receptor variant and risk of dementia and white matter lesions},
  author={Elisabeth F. C. van Rossum and Frank de Jong and Jan Willem Koper and Andr{\'e} G. Uitterlinden and Monique M. B. Breteler},
  journal={Neurobiology of Aging},
OBJECTIVE Elevated glucocorticoid levels are associated with dementia. A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities. METHODS This study was performed in two prospective population-based cohort studies among elderly. The first study included 6034 participants who were screened for dementia (mean follow-up 5.8 years). The second… CONTINUE READING


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