Glucocorticoid receptor signaling in the intestinal epithelial cell lines IEC-6 and Caco-2: evidence of inhibition by interleukin-1β

@article{Raddatz2001GlucocorticoidRS,
  title={Glucocorticoid receptor signaling in the intestinal epithelial cell lines IEC-6 and Caco-2: evidence of inhibition by interleukin-1β},
  author={Dirk Raddatz and Szilvia T{\'o}th and Harald Schwoerer and Giuliano Ramadori},
  journal={International Journal of Colorectal Disease},
  year={2001},
  volume={16},
  pages={377-383}
}
Background and aims: Glucocorticoids are potent anti-inflammatory drugs widely used in the treatment of inflammatory bowel disease, but many patients do not benefit from glucocorticoid therapy (glucocorticoid resistance) or need inappropriately high doses to retain remission (glucocorticoid dependency). Because of the role of intestinal epithelial cells in inflammatory bowel disease we examined glucocorticoid receptor signaling and the effect of interleukin-1β as one of the main proinflammatory… CONTINUE READING