Glucocorticoid receptor physiology

  title={Glucocorticoid receptor physiology},
  author={Marjet D. Heitzer and Irene M. Wolf and Edwin R. S{\'a}nchez and Selma Feldman Witchel and Donald B DeFranco},
  journal={Reviews in Endocrine and Metabolic Disorders},
Glucocorticoid action in cells is mediated by a specific receptor protein, the glucocorticoid receptor (GR). GR is a member of a superfamily of ligand-inducible transcription factors that control a variety of physiological functions; such as, metabolism, development, and reproduction. Unliganded GR is predominantly localized within the cytoplasm but rapidly and efficiently translocates to the nucleus following hormone binding. This review will focus on the intracellular signaling pathway… CONTINUE READING


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