Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis

@article{Akker2009GlucocorticoidRM,
  title={Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis},
  author={Erica L.T. van den Akker and Jan Willem Koper and K F M Joosten and Frank H. de Jong and Jan A. Hazelzet and Steven W. J. Lamberts and Anita C. S. Hokken-Koelega},
  journal={Intensive Care Medicine},
  year={2009},
  volume={35},
  pages={1247 - 1254}
}
  • Erica L.T. van den Akker, Jan Willem Koper, +4 authors Anita C. S. Hokken-Koelega
  • Published in Intensive Care Medicine 2009
  • Medicine
  • ObjectiveCorticosteroids are used in sepsis treatment to benefit outcome. However, discussion remains on which patients will benefit from treatment. Inter-individual variations in cortisol sensitivity, mediated through the glucocorticoid receptor, might play a role in the observed differences. Our aim was to study changes in mRNA levels of three glucocorticoid receptor splice variants in neutrophils of children with sepsis.Patients and designTwenty-three children admitted to the pediatric… CONTINUE READING

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