Glucocorticoid receptor mRNA in patients with ulcerative colitis: a study of responders and nonresponders to glucocorticosteroid therapy.

@article{Flood2001GlucocorticoidRM,
  title={Glucocorticoid receptor mRNA in patients with ulcerative colitis: a study of responders and nonresponders to glucocorticosteroid therapy.},
  author={Lisa Flood and Robert L{\"o}fberg and Pontus Stierna and A C Wikstr{\"o}m},
  journal={Inflammatory bowel diseases},
  year={2001},
  volume={7 3},
  pages={
          202-9
        }
}
BACKGROUND AND AIMS Up to 30% of patients with severe-to-moderate attacks of ulcerative colitis (UC) respond poorly to glucocorticosteroid (GCS) treatment. The reason for this unresponsiveness is unknown. AIM Our aim was to evaluate possible differences in glucocorticoid receptor (GR) density in peripheral leukocytes and effects of low-dose GCS treatment on GR density and on the hypothalamic-pituitary-adrenal axis in UC patients who had received high-dose GCS treatment due to a moderate or… CONTINUE READING

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