Glucocorticoid receptor mRNA expression in peripheral blood mononuclear cells in high trained compared to low trained athletes and untrained subjects.

@article{Bonifazi2009GlucocorticoidRM,
  title={Glucocorticoid receptor mRNA expression in peripheral blood mononuclear cells in high trained compared to low trained athletes and untrained subjects.},
  author={Marco Bonifazi and Monica Mencarelli and Valentina Fedele and Ilaria Ceccarelli and Alessandra Pecorelli and Giuseppe Grasso and Anna Maria Aloisi and Michela Muscettola},
  journal={Journal of endocrinological investigation},
  year={2009},
  volume={32 10},
  pages={816-20}
}
BACKGROUND Physiological needs during prolonged exercise are a potent stimulus for the hypothalamic-pituitary-adrenal (HPA) axis. Hence, athletes undergoing daily endurance training sessions may have frequent and prolonged phases of endogenous hypercortisolism. Since chronic glucocorticoids treatment leads to down-regulation of glucocorticoid receptor alpha (GR-alpha) mRNA expression, endurance training could lead to modulation of GR expression. AIM The aim of the study was to evaluate GR… CONTINUE READING