Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.

@article{Bresnick1990GlucocorticoidRD,
  title={Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.},
  author={Emery H. Bresnick and Susan John and Diana Berard and Philippe Lefebvre and Gordon L. Hager},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 10},
  pages={3977-81}
}
Our laboratory has previously developed cell lines derived from mouse NIH 3T3 fibroblasts and C127 mammary tumor cells that stably express mouse mammary tumor virus (MMTV) long terminal repeat fusion genes in bovine papillomavirus-based episomes. Glucocorticoid hormone strongly activates transcription from episomes and induces the disruption of a single nucleosome in an array of phased nucleosomes on the MMTV promoter. Sodium butyrate inhibits the glucocorticoid hormone-dependent development of… CONTINUE READING

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