Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction.

@article{Taniguchi2010GlucocorticoidRA,
  title={Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction.},
  author={Yoshinori Taniguchi and Yasumasa Iwasaki and Makoto Tsugita and Mitsuyo Nishiyama and Takafumi Taguchi and Mizuho Okazaki and Shuichi Nakayama and Machiko Kambayashi and Kozo Hashimoto and Yoshio Terada},
  journal={Endocrinology},
  year={2010},
  volume={151 7},
  pages={
          3204-13
        }
}
Glucocorticoid has diverse biological effects through induction or repression of its target genes via glucocorticoid receptor (GR). In addition to the wild-type GR (GR-alpha), a variety of GR variants has been reported, and these are thought to modify glucocorticoid action. Among others, GR-beta is reported be responsible for the glucocorticoid resistance frequently observed in steroid-resistant nephrotic syndrome, rheumatoid arthritis, and hematologic tumors, although the precise molecular… CONTINUE READING
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