Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.

@article{Bosscher1997GlucocorticoidmediatedRO,
  title={Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.},
  author={Karolien De Bosscher and Michael Schmitz and Wim Vanden Berghe and St{\'e}phane Plaisance and Walter Fiers and Guy Haegeman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 25},
  pages={13504-9}
}
Glucocorticoids exert multiple anti-inflammatory activities, one of which is the inhibition of transcription dependent on the nuclear factor (NF)-kappaB. It has been suggested that the effect of dexamethasone (DEX), a glucocorticoid analog, is attributed to an increased production of the inhibitory IkappaB molecule, which in turn would bind and remove activated, DNA-bound NF-kappaB complexes in the cell nucleus. Upon investigating DEX-mediated repression of interleukin-6 expression induced by… CONTINUE READING

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De Bosscher et al

  • A. Ray, Prefontaine, 91 K.E.Proc.Natl.Acad.Sci.USA, 752–756. FIG. 5. DEX does not interfere with Gal4 binding t Biochemistry
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

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