Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain.

@article{Garside2004GlucocorticoidLS,
  title={Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain.},
  author={Helen J Garside and Adam Stevens and Stuart Farrow and Claire Normand and Benoit Houle and Andy Berry and Barbara Maschera and David Ray},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 48},
  pages={50050-9}
}
Glucocorticoids inhibit inflammation by acting through the glucocorticoid receptor (GR) and powerfully repressing NF-kappaB function. Ligand binding to the C-terminal of GR promotes the nuclear translocation of the receptor and binding to NF-kappaB through the GR DNA binding domain. We sought how ligand recognition influences the interaction between NF-kappaB and GR. Both dexamethasone (agonist) and RU486 (antagonist) promote efficient nuclear translocation, and we show occupancy of the same… CONTINUE READING
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